Fact Versus Supposition
Data and Theory Advance Science
Improvements in technology, communication of results, experiments designed to test specific hypotheses, careful observation, insightful interpretation all advanced our knowledge and understanding of our world and eliminated many inaccurate beliefs that arose out of ignorance and creative explanation.

homunculus:http://privatewww.essex.ac.uk/~canessa/images1.htm
Inheritance
It was obvious to our ancestral observers that breeding of males and females resulted in offspring that were different from each parent but bore characteristics of each. Many thought that fluids from the two parents blended together to produce the children. When sperm were first observed after the invention of the microscope (1670s), people thought they saw a small man (the homunculus, or "little man") in the head of the sperm that was destined to be the new individual, and animalculists believed that the mother's role was only to provide a place for development of the future human being seen in the sperm. In the same decade, the ovary was described for the first time, and ovists believed the future human being was in the egg and the male fluid merely stimulated the egg to grow.

The hypothesis of blending inheritance, in which the hereditary material was mixed into a blend, did not match the results of breeders trying to develop new plant varieties. The hypothesis predicted that sexual reproduction would lead to blending that logically would result eventually in complete uniformity of characteristics. In contrast, parental characters reappeared in later generations, preserving the diversity among individuals. Gregor Mendel, through careful breeding experiments, deduced that there were units of inheritance that followed rules and persisted unchanged through the generations.

Quantum Mechanics
In the time of Isaac Newton (1642-1727), it was believed that light traveled in straight lines. Because of Newton's great reputation and authority, his theory that light consists of particles was accepted for more than a century. Then, in the 1800s, numerous experiments diffracted light and showed that it behaved as a wave. The classical wave theory of light culminated in 1860 when James Maxwell published his mathematical theory of electromagnetism, and concluded that light is an electromagnetic wave.

photoelectric effect:https://www.llnl.gov/str/June05/Aufderheide.html
A light source shining on a metal surface causes electrons to be emitted from the metal and produce a current (the photoelectric effect). According to the classical theory, increasing the intensity (brightness) of the light that falls on a metal surface would increase the energy absorbed by individual electrons and, so, would also increase the maximum kinetic energy of the electrons emitted. Surprisingly, the maximum kinetic energy of the electrons emitted is the same for a given wavelength of incident light no matter how intense the light is. Experiments in the early 1900s showed that the maximum kinetic energy of the electrons emitted is proportional to the frequency of the incident light.

Summary
In both these cases, scientists and others did their best to propose hypotheses that fit the observations and were consistent with their contemporary culture. As improvements in technology made it possible to gather additional evidence with accurate measurements, inconsistencies between the new data and the initial hypotheses led to better understanding of natural phenomena that opened the doors to further scientific progress. Strong loyalties to perceptions that the new details showed were inaccurate made it difficult for many non-scientists at that time to accept the new ideas that we now take for granted.
Excerpted and adapted from:
1. Curtis, H., and N. S. Barnes. 1989. Biology. Worth Publishers, Inc., NY
2. Tipler, Paul A., and Gene Mosca. 2008. Physics for Scientists and Engineers. W. H. Freeman and Company, NY. 6th Edition, p 1174-1177.