Camissonia confertiflora is most closely related to C. brevipes and C. multijuga. All three species are in the same subgenus Chylismia. C. confertiflora is known only from the type locality and has only been collected four times after winters with above average precipitation, or greater than 12 inches. C. brevipes ranges from Nevada, to western Arizona, and southeastern California, while C. multijuga ranges from Colorado to Nevada, Arizona and California. C. confertiflora is endemic to Grand Canyon National Park. Camissonia, is named for L.A. Chamisso, French-born German botanist, 1781-1838, while confertiflora literally means crowded flowers.

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